Sunday, 19 February 2017

Flow cytometry markers :

Flow cytometry markers :
CD1a, S-100, CD-207(Langherin)- Langerhan cell histiocytosis
CD 2 3 4 5 7 8- T-cell markers,CD3 is pan T cell marker
CD10 (aka CALLA antigen) : Early pre B marker,immature B cell marker
CD 11c, 25, 103, 123 : Hairy cell lukemia (CD 123 Most specific)
CD 13,33,117, MPO: Myeloid series marker-AML
CD 14,64: Monocyte marker (AML-M4 M5)
CD 15 : RS cell,Neutrophils
CD 15,30 : RS Cell
CD 16,56: NK Cell
CD 19,20,21,22 : B Cell markers, CD 19 is pan B cell marker
CD 23+,CD 5+ : CLL/SLL
CD 23-,CD 5+ : Mantle cell lymphoma
CD 30(only) aka Ki-antigen : Anaplastic Large cell lymphoma
CD 31: Endothelial cell marker (positive in angiosarcomas)
CD 34: Stem cell (also positive in angiosarcomas)
CD 41,61: Megakaryocyte,platelet marker,positive in AML-M7
CD 45 : On all leukocytes(except RS cell)
CD 45 RO: Memory cell
CD 45RA/RB: Naive B/T Cell
CD 55(DAF), CD 59(MIRL) : Absent in PNH
CD 68,S-100+ :Histiocyte marker(+ in malignant fibrous histiocytosis)
CD 95/FAS ligand: apoptosis marker (extrinsic pathway)
CD 99/MIC-2 : Ewings sarcoma
CD 103: Hairy cell
CD 117 :GIST,Mastocytosis,AML (117 is present on mast cells also)
CD 123: New antibody in Hairy cell leukemia
CD 133:Glioma
CD 207(Langherin): LCH
CD 235(Glycophorin): AML-M6

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