Thursday, 23 June 2016

Various types of haemoglobin

Various types of haemoglobin :-

Adult haemoglobin :-

Hb A - two alpha and two beta chains

Hb A2- two alpha and two delta chains 

Fetal haemoglobin :-

Hb F- two alpha and two gamma chains 

Embryonic haemoglobin :-

Gower 1- two zeta and two epsilon chains 

Gower 2- two alpha and two epsilon chains 

Portland - 1 - two zeta and two gamma chains 

Portland 2- two zeta and two beta chains 

In alpha thalessemia :-

Hb Bart - tetramer consisting of four gamma chains 

HbH - tetramer consisting of four beta chains

Miscellaneous :-

Haemoglobin S - glutamic acid is replaced by valine at 6 th position of beta chain 

Haemoglobin C - glutamic acid is replaced by lysine at 6 th position of beta chain 

Haemoglobin E - glutamic acid is replaced by lysine at 26 th position of beta chain

Haemoglobin M. Iwata - histidine is replaced by tyrosine at 87th position at alpha chain; associated with methhaemoglobinemia

HEMOGLOBIN M (Milwaukee) is a rare dominant hereditary disorder where glutamate replaces valine in position 67 on the beta chain of the hemoglobin molecule

Haemoglobin lepore :-

Two alpha and two ( delta - beta fusion ) chains

Haemoglobin produced by yolk sac- Gower 1 Gower 2 and Portland

By liver- HB F

By bone marrow- HB A

At term 70% is HB F

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