Tuesday, 22 December 2015

IgA Nephropathy

IgA nephropathy is the most common form of glomerulonephritis worldwide.
There is male preponderance, peak incidence is in the second & third decades of life.
Two most common clinical presentations are:
● Recurrent episodes of macroscopic hematuria.
● Persistent asymptomatic microscopic hematuria.
Renal histological features of HSP nephritis is strikingly similar to those of IgA nephropathy.

IgA Nephropathy

Aphemia is a severe form of acute speech apraxia that presents with severely impaired fluency.
‪Warfarin is not contraindicated in lactating mothers.
Serum lithium level should be checked earliest after 5 days of constant dosing.
Gamma Gandy bodies contain hemosiderin & calcium.
Internucleosomal cleavage of DNA is characteristic of apoptosis.
Most common form of dissociation hysteria is amnesia.
Relapse rate of P.vivax malaria in India is 30%.
Radiation dose of barium enema is equal to 350 X-rays.
Ram's horn & Pseudobillroth appearance on barium studies is a feature of Crohn's disease.
Thiazides decrease positive free water clearance.
Carbohydrate, protein & fat metabolism occur in TCA cycle.
Monosaccharides seperation is by chromatography technique.
Papillary hidradenoma occurs most commonly in anogenital region.
Most common location for performing endomyocardial biopsy is right ventricle.
Earliest immunoglobulin to appear in fetus is IgM.
Cow milk contains soluble radioactive substance - Strontium 90.
Earliest visual field defect in Glaucoma is isopter contraction but paracentral scotomas are more specific.
Paracrine regulation refers to factors released by one cell that act on an adjacent cell in the same tissue.
For example, somatostatin secretion by pancreatic islet delta cells inhibits insulin secretion from nearby beta cells.
Autocrine regulation describes the action of a factor on the same cell from which it is produced. IGF-1 acts on many cells that produce it, including chondrocytes, breast epithelium & gonadal cells.

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