Saturday, 26 December 2015

AMBIGUOUS LEUKEMIA

AMBIGUOUS LEUKEMIA

3 TYPES:

1) UNDIFFERENTIATED ACUTE LEUKEMIAS:
Lack morphologic or immunologic differentiating features;
Blasts cell express HLA-DR,CD34,CD38,TdT( terminal deoxynucleotidase) and CD7.

2) BILINEAL ACUTE LEUKEMIA:
Two populations of blasts expressing distinct lineage markers of myeloid or lymphoid origin or B- and T-cell lineage

3) BIPHENOTYPIC ACUTE LEUKEMIA:
Same Blast cell coexpress myeloid and lymphoid antigen both ..usually seen in BLAST CRISES OF CHRONIC MYELOID LEUKEMIA

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