Thursday, 10 September 2015

Influenza

INFLUENZA VIRUS
Asked Points :
Influenza A - Hemagglutinin and neuraminidase is strain specific
Influenza - Primary infectious pneumonia is less common than secondary bacterial pneumonia
Influenza - Major epidemics are due to antigenic SHIFT, Antigenic drift is gradual antigenic
change over a period of time, Antigenic shift is due to genetic recombination of virus, Influenza
A is subjected to frequent antigenic variations Segmented RNA - Influenza

H5N1 - Bird flu virus
Gradual and sequential change in antigenic structure at regular intervals - Antigenic drift
Influenza causes new epidemic by - Antigenicndrift
Antigenic shift - Gradual
Antigenic variation NOT seen in - Influenza C
Influenza - Affects all sexes and ages, Incubation period 18 – 72 hours
Immunofluorescence - Detection of influenza
Amantidine is most effective for - Influenza A
Which is a Neuraminidase Inhibitor - Oseltamivir
Avian influenza treated by - Oseltamivir
Oseltamivir is used to treat - Influenza A & B
Newer influenza vaccine - Split virus vaccine,
Neuraminidase, Recombinant vaccine

Harrison Points :
H1N1 swine flu was found on - 2009
Influenza is associated with - Myositis and rhabdomyolysis
Most serious complication of Influenza B - Reye syndrome
Amantidine and rimantidine are active against - Influenza A only
Oseltamivir inhibit - Neuraminidase

Additional Points :
Segmented RNA virus - Influenza virus
M protein in orthomyxovirus maturation - Serves as a recognition site for nucleocapsid at the
inner face of plasma membrane
All pandemic of influenza by - Influenza A only
Pandemic of influenza is caused by - Antigenic shift
Shift occurs only with - Influenza A
Reye syndrome is associated with - Influenza B
Mechanism of action of oseltamivir - Inhibition of a viral enzyme that aids the spread of virus
through respiratory mucus and is required for release of progeny virus
Dose of oseltamivir in adults - 75 mg BD

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