Wednesday, 8 April 2015

IL

1.IL-1 Secreted by macrophages. Causes acute inflammation (1 = alpha)A = acute inflammation (Increase pg), L = Leukocytosis = (activate with chemokines)F= fever, A = adhesion molecules are put on endothelial cells

2.IL-2 Secreted by Th cells. Stimulates growth of Th and CTL cells.

3.IBD is caused by - due to a deficiency in (IBD) = T cell dysregulation following IL-2 deficiency

4.Drugs against IL-2. What are they called, function and uses Basiliximab, daclizumab (transplantation) anti-IL-2 monoclonal antibodies, Cylcosporine = T cell response blocker (decreases IL-2) = transplantation, rheumatoid arthritis

5.IL-3 Secreted by activated T cells. Supports the growth and differentiation of bone marrow stem cells, has a function similar to GM-CSF

6.IL-4 Secreted by Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG. (B means 2 in order = 4 Equals 2 in order) B cell + 2(Th2) = (IgEquals) IL4.

7.IL-5 Secreted by Th2 cells. Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates production of acute-phase reactants and eosinophils (Give the high-five for the person who got an AcE) = IgA, Eosinophil

8.IL-6 secreted by Th cells and macrophages. Stimulates production of acute phase reactants and immunoglobulins. (Sick with a fever at 6).

9.Fever is caused by 3 pyrogens: TNF-alpha, IL-1, IL-6

10.IL-8 (CXCL8): Secreted by macrophages. "What I 8 is Neutritious. (Attract neutrophils via chemotaxis)

11.IL-10 :Secreted by regulatory T cells. inhibits activation of activated T cells.

12.IL-12 :Secreted by B cells and macrophages. Activates natural killer cells and Th1 cells. (The 12V bulb on macrophage wants TELLs 1 helper (TH1) and 2 killers (CTL and NK) to produce IFN-gamma (1 + 2= gamma = 3 by order).

13.Decrease in IFN-gamma caues Increased infections by intracellular microbes such as listeria monocytogenes and mycobacteria

14.IFN gamma: Secreted by Th1 cells. Stimulates macrophages. Mediates septic schok, causes leukocyte recruitment, vascular leak

15.Helper T cells :CD4, TCR, CD3, CD28, CD40L

16.Cytotoxic T cells :CD8, TCR, CD3

17.B cells :IgM, B7, CD19, CD20, CD21, CD40, MHC II

18.Which Cell surface proteins is the receptor for EBV? CD21

19.Macrophages MHC II, B7, CD40, CD14, Receptors for Fc and C3b

20.NK Receptors for MHC1, CD16 (binds Fc of IgG), CD56,

21.All cells except RBC MHC1

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