Wednesday, 8 April 2015

Cushing's in medicine



📌CUSHING ULCER-A gastric ulcer produced by elevated intracranial pressure. It is also called von Rokitansky syndrome. Apart from in the stomach, it may also develop in the proximal part of the duodenum and the distal esophagus.

📌CUSHING REFLEX/EFFECT/REACTION-is a physiological nervous system response to increased intracranial pressure (ICP) that results in Cushing's triad of increased blood pressure, irregular breathing, and a reduction of the heart rate. It is usually seen in the terminal stages of acute head injury and may indicate imminent brain herniation. It can also be seen after the intravenous administration of epinephrine and similar drugs

📌CUSHINGS TRIAD- (not to be confused with the Cushing reflex) is a sign of increased intracranial pressure. It is the triad of:

1. Hypertension (progressively increasing systolic blood pressure)

2. Bradycardia

3. Widening pulse pressure (an increase in the difference between systolic and diastolic pressure over time)

Cushing's triad suggests a cerebral hemorrhage in the setting of trauma or an space occupying lesion (e.g. brain tumor) that is growing and a possible impending fatal herniation of the brain.

📌CUSHINGS SYNDROME-hypercortisolism, , and , is a collection of signs and symptoms due to prolonged exposure to cortisol.Signs and symptoms may include: high blood pressure, abdominal obesity but with thin arms and legs, reddishstretch marks, a round red face, a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals poorly. Women may have more hair andirregular menstruation. Occasionally there may be changes in mood, headaches, and achronic feeling of tiredness.

📌CUSHINGS DISEASE-characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (hypercortisolism). This is most often as a result of a pituitary adenoma (specifically pituitary basophilism) or due to excess production of hypothalamus CRH (Corticotropin releasing hormone) (hypercortisolism/hypercorticism) that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome,when excluding Cushing's syndrome from exogenously administered corticosteroids.

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