Wednesday, 1 April 2015

Antispasmodic drugs

A. Quarternary compounds -
propantheline,
oxyphenonium
Clidinium
Glycopyrrolate

B. Tertiary amines -
Dicyclomine
Valethamate
Pirenzepine

C. Vasoselective -
Oxybutynin
Tolterodine
Flavoxate

D. Drotaverine
All r anticholinergics except Drotaverine.
Drotaverine is nonanticholinergic smooth muscle antispasmodic. It inhibits PDE4 (selective for smooth  muscle). So cAMP/cGMP increased.
Used in intestinal biliary renal n uterine spasm n IBS.

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