Sunday, 1 March 2015

Tumour Markers

Various Markers::
1. Tumours of epithelial origin - cytokeratin
2. Tumours of mesenchymal origin - vimentin
3. Tumours of smooth muscle origin - smooth muscle actin, desmin
4. Tumours of skeletal muscle origin - desmin
5. Glial origin - GFAP
6. Vascular origin - vWF, CD 31, factor viii, VEGF
7. Stem cells - CD 34
8. B cells - CD 19, 20, 21, 22
9. Pan B cells - CD 19
10. T cells - CD 1,2,3,5,7
11. Pan T cells - CD 3
12. NK cells - CD 16,56
13. Reed sternberg cell - CD 15, 30
14. Popcorn RS cell - CD 20, 45
15. Mantle cell lymphoma - cyclin d1, CD 5
16. Chronic lymphocytic leukaemia - CD 5, CD 23
17. Hairy cell leukaemia - annexin a1, CD 25, 103, 11c
18. Seminoma - PLAP, HCG
19. Choricarcinoma - HCG
20. Yolk sac tumour - AFP
21. Sertoli cell tumour - inhibin
22. Neuroendocrine tumour - NSE, synaptophysin, chromogranin
23. Medullary carcinoma thyroid - calcitonin
24. Ewing's sarcoma - CD 99, mic 2
25. Malignant melanoma - HMB 45, S 100
26. GIST - DOG 1, CD 117, CD 34
27. Apoptotic cells - annexin

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