Wednesday, 18 February 2015

RET Oncogene

RET proto oncogene encodes for - Tyrosine kinase receptor on cytoplasmic membrane 
RET ligand is identified as - Glial cell line derived neurotrophic factor (GDNF) 
RET - Chromosome 10 
NOT a differentiating thyroid cancer - Medullary carcinoma 
Point mutation of RET - Medullary carcinoma thyroid 
Medullary carcinoma thyroid is common in - Superior pole 
Medullary carcinoma thyroid is associated with - Osteoblastic skeletal metastasis 
Most aggressive medullary carcinoma of thyroid is associated with - MEN IIB 

Thyroid carcinoma secreting ACTH - Medullary carcinoma 
Ectopic ACTH secretion is associated with - Medullary carcinoma thyroid 
All Thyroid cancer From Follicular Cells EXCEPT - Medullary carcinoma thyroid from parafollicular cells (c cells) 
ACal - Medullary Carcinoma Thyroid 
RET Protooncogene - Medullary carcinoma 
Medullary carcinoma of thyroid arise from - Parafollicular cells 
Multiple submucosal neuroma associated with - Medullary carcinoma thyroid 
Amyloid like stroma - Medullary carcinoma 
Thyroid carcinoma associated with hypocalcemia - Medullary carcinoma 
MC Presentation of Medullary Carcinoma Thyroid - Diarrhoea 
Medullary carcinoma of thyroid NOT associated with - Antibodies 

Most important predictor of medullary carcinoma thyroid - CEA 

Treatment of medullary carcinoma thyroid - Surgery only 
Treatment of Medullary carcinoma - Total thyroidectomy 
Treatment of medullary carcinoma with lymph node metastasis - Total thyroidectomy with radiotherapy 
Palpable thyroid nodule demonstrating amyloid stroma, cervical lymphnode on the same side of lesion - Total thyroidectomy and modified neck dissection on the side of enlarged lymph node 
NOT true about diagnosis of medullary carcinoma thyroid - Histological mitochondria is essential for diagnosis

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