Friday, 9 January 2015

Inflammatory bowel disease

Inflammatory bowel disease

1) Appendicectomy is protective for Ulcerative Colitis
2) Smoking is protective for Ulcerative Colitis
3) Concordance in genetic twins is much more common in Crohn's than Ulcerative Colitis
4) NF-kB is the main transcription factor implicated in pathogenesis of IBD
5) Most common site for UC - Rectosigmoid junction
6) Most common site for Crohn's - Ileocecal junction
7) Crohn's can involve any part of GIT except - Rectum
8) Most common symptom of UC - Bloody diarrhoea
9) Most common symptom of Crohn's disease - Small bowel diarrhea
10) Lead pipe appearance or Pipe stem appearance - UC
11) Hose pipe appearance - Crohn's
12)  DIAGNOSIS OF UC
-------------> Most sensitive test - Fecal calprotectin
-------------> Most specific test -Colonoscopy and guided biopsy
-------------> Most sensitive and specific -Colonoscopy and guided biopsy
13) DOC for Ulcerative colitis - 5 ASA agents
14) DOC for resistant Ulcerative Colitis - TNF alpha agents
15) DOC for Crohn's disease - TNF alpha agents
16) Latest drug for treatment of IBD - Vedolizumab - Its a ''alpha4 beta 7'' integrin inhibitor
17) Two extra -intestinal manifestations of IBD which DO NOT revert with treatment
( Reference 18th edition Harrison)

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