Wednesday, 5 November 2014

SSRI

POINTS TO REMEMBER IN SSRI(KAPLAN):

1. first ssri discovered was fluoxetine
2. only ssri approved for childhood depression - fluoxetine
3. longest half life - fluoxetine
4. does not require dose tapering/does not cause withdrawal - fluoxetine
5. ssri having maximum anticholinergic effect - paroxetine
6. ssri having maximum sedation - paroxetine
7. ssri least safe in elderly - paroxetine 
8. Fluvoxamine, paroxetine, sertraline, and fluoxetine are indicated for treatment of OCD in persons over the age of 18 years. 
9. Fluvoxamine and sertraline have also been approved for treatment of pediatric OCD (ages 6 to 17)
10. most common long term associated side effects of ssri - sexual dysfunction(manifests as anorgasmia)... it does not decrease with continued usage
11. mc side effects are gi side effects (bcoz of 5ht3 receptors) include nausea, diarrhea, anorexia, vomiting, flatulence, and dyspepsia... (aiims question loose stools >> anxiety)  
12. mc ssri implicated in causing paradoxical anxiety - fluoxetine
13. mc ssri blamed to cause increase in suicidal risk especially in children - fluoxetine 
14. mc ssri causing insomnia - fluoxetine
15. ssri with shortest half life - fluvoxamine
16 .ssri with most enzyme inhibition - fluvoxamine 
17.ssri with most drug interactions - fluvoxamine 
18.all ssri are us fda approved for depression except - fluvoxamine
19.  rare s.e of ssri includes - SIADH...

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