Wednesday, 6 August 2014

Side effects

..........S/E or Advr effects.......

Agranulocytosis........ Clozapine

Aplastic Anemia......· Chloramphenicol · NSAIDs

Atropine-like Side Effects............Tricyclics

Cardiotoxicity.............· Doxorubicin · Daunorubicin

Cartilage Damage in children......Fluoroquinolones

Cinchonism............Quinidine

Coronary Steal Phenomenon...........Dipyridamole

Corneal micro deposits...........· Amiodarone

Cough.........· ACE Inhibitors

Diabetes Insipidus............Lithium

Disulfiram-like effect..............Metronidazole · Sulfonylureas (1st generation)

Extrapyramidal Side Effects........Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Fanconi’s Syndrome.........Tetracycline

Fatal Hepatotoxicity (necrosis)........· Valproic Acid · Halothane · Acetaminophen

Gingival Hyperplasia......· Phenytoin

Gray Baby Syndrome...........Chloramphenicol

Gynecomastia.........

Cimetidine · Azoles · Spironolactone · Digitalis · Estrogen & testosterone · INH & ethionamide · Clomiphine · Phenytoin · Reserpine & Methyldopa

Hand Foot Syndrome..........· 5-Flurouracil (5-FU)

Hemolytic Anemia in G6PD-deficiency

· Sulfonamides · Isoniazid · Aspirin · Ibuprofen · Primaquine

Hemorrhagic Cystitis

· Cyclophosphamide · Ifosamide
(Treat by Mesna & Acetylcysteine Bladder Wash)

Hepatitis...........· Isoniazid

Hot Flashes, Flushing

· Niacin · Tamoxifen · Ca++ Channel Blockers

Hypertension: Postural............· Prazocin

Hypertension: Rebound............· Clonidine withdrawal

Increased intra cranial tension ( ICT)

· Amiodarone · Hypervitaminosis A · OCP’s · Tetracycline · Quinolones

Induce CP450

· Barbiturates · Phenytoin · Carbamazepine · Rifampin

Inhibit CP450

· Cimetidine · Erythromycin · Ketoconazole · Isoniazid

Interstitial Nephritis

· Methicillin · NSAIDs (except Aspirin) · Furosemide · Sulfonamides

Milk Alkali Syndrome......· Calcium Carbonate

Nephrotoxicity.....· Cephaloridine · Gentamycin · Amphotericin

Orange Body Fluids............· Rifampin

Osteoporosis...........· Heparin · Corticosteroids

Pancreatitis............· L-Asparginase · Glucocorticoids

Photosensitivity...........· Lomefloxacin · Pefloxacin

Positive Coombs’ Test........· Methyldopa

Pulmonary Fibrosis............· Bleomycin · Amiodarone

Rabbit Syndrome (Perioral tremors).........· Phenothiazines

Red Man Syndrome.............· Vancomycin (rapid IV)

SLE- Drug Induced [Anti Histone Antibody}

· Chloropromazine · Hydralazine · Isoniazid · Methyldopa · Procainamide · Quinidine

Tardive Dyskinesia

· Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Tinnitus...........· Aspirin · Quinidine

Torsades de Pontis...........Terfanadine

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