Thursday, 8 May 2014



• class of neurodegenerative diseases associated with the pathological aggregation of TAU PROTEIN in the human brain.
• tau protein is deposited within neurons in form of neurofibrillary tangles (NFTs).
• Tangles (NFT=a/k/a---PHF or "paired helical filaments") are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form (also referred to as ).
• It consists of following disorder:-

1. Alzheimer disease
2. Pick's disease
3. corticobasal degeneration
4. progressive supranuclear palsy
5. Dementia pugilistica (chronic traumatic encephalopathy)
6. Frontotemporal dementia and parkinsonism linked to chromosome 17,
7. Lytico-Bodig disease (Parkinson-dementia complex of Guam)
8. Ganglioglioma and gangliocytoma
9. Meningioangiomatosis
10. Subacute sclerosing panencephalitis
11. Frontotemporal dementia
12. Frontotemporal lobar degeneration
13. lead encephalopathy,
14. tuberous sclerosis, Hallervorden-Spatz disease, and lipofuscinosis

• group of neurodegenerative disorders characterized by fibrillary aggregates of ALPHA-SYNUCLEIN PROTEIN in the cytoplasm of neurons and glia.
• These disorders include:-
• Parkinson's disease (PD)
• dementia with Lewy bodies (DLB)
• pure autonomic failure (PAF)
• multiple system atrophy (MSA)

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