Friday, 18 April 2014

Beta Blockers

Beta blockers
*🔹Beta blockers are drugs which act against the beta adrenergic
receptors. There are three kinds of adrenergic receptors namely beta1,
beta2 and beta3.
*🔹First generation beta blockers (non-selective beta blockers) :
- Propranolol
- Nadolol
- Timolol
- Penbutalol
- Pindolol
- Oxprenolol
- Alprenolol
*🔹Second generatin beta blockers ( Beta1 selective beta blockers =
Cardioselective beta blockers ):
- Acebutalol
- Celiprolol
- Bisoprolol
- Metaprolol
- Nebivolol (most cardioselective beta blocker)
- Atenolol
- Esmolol
- Betaxolol
*🔹Third generation beta blockers ( These are beta blockers which have
additional vasodilator property ):
- Labetalol and Carvedilol ( act as vasodilators by antagonising
alpha1 receptors on blood vessels)
- Tilosolol ( act as vasodilator by opening up potassium channels)
- Nebivolol and Nipradilol ( generate Nitric oxide )
- Bevantolol, Betaxolol, Carvedilol ( inhibit calcium channels )
- Bopindolol, Carteolol, Celiprolol ( agonists of beta2 receptors )
* 🔹Beta blockers with Membrane stabilising activity (local anaesthetic
activity) :
- Propranolol (most effective)
- Labetalol
- Acebutolol
- Metaprolol
- Pindolol
*🔹 Beta blockers with intrinsic sympathomimetic activity :
- Oxprenolol
- Alprenolol
- Pindolol
- Celiprolol
* Beta blockers which are lipid insoluble ( so they are excreted by
kidney and hence contraindicated in renal failure - LONG ACTING
AGENTS ) :
- Nadolol
- Sotalol
- Acebutalol
- Atenolol
- Betaxolol
- Bisoprolol
- Celiprolol
*🔹 Longest acting beta blocker is Nadolol
*🔹 Shortest acting beta blocker is esmolol.

No comments:

Post a comment