Sunday, 8 December 2013

Rhabdomyosarcoma

Rhabdomyosarcoma, the most common soft-tissue sarcoma of childhood and adolescence, usually appears before age 20.It may arise in any  anatomic location, but most occur in the head and neck or genitourinary tract, where there is little if any skeletal muscle as a normal constituent.

Embryonal rhabdomyosarcoma is the most common type, accounting for 60% of rhabdomyosarcomas. It includes the sarcoma botryoides.

Alveolar rhabdomyosarcoma tends to develop in early to middle adolescence, commonly arises in the deep musculature of the extremities, and represents approximately 20% of rhabdomyosarcomas.

Pleomorphic rhabdomyosarcoma is characterized by numerous large, sometimes multinucleated, bizarre
eosinophilic tumor cells.

The botryoid subtype has the best prognosis, while the anaplastic embryonal, pleomorphic, and alveolar variants are often fatal.

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