Monday, 2 December 2013

Cytokines and antiviral

Name Major Cellular Source Selected Biologic Effects
IFN-α, β Macrophages (IFNα)
fibroblasts (IFNβ)
IFN-γ CD4+ T cells, NK cells Activates macrophages, TH1 differentiation
TNF-α Macrophages, T cells Cell activation, Fever, cachexia, antitumor
TNF-α, LT (lymphotoxin) T cells Activates PMNs
IL-1 Macrophages Cell activation, Fever (Pro inflammatory)
IL-2 T cells T cell growth and activation
IL-3 T cells Hematopoiesis
IL-4 T cells, mast cells B cell proliferation and switching to IgE, TH2 differentiation
IL-5 T cells Differentiation of eosinophil, activates B cells
IL-7 Bone marrow stroma cells T cell progenitor differentiation
IL-8 Macrophages, T cells Chemotactic for neutrophils
IL-10 Macrophages, T cells Inhibits activated macrophages and dendritic cells, Anti-inflammatory
IL-12 Macrophages Differentiation of T cells, activation of NK cells
GM-CSF T cells, macrophages, monocytes Differentiation of myeloid progenitor cells
M-CSF Macrophages, monocytes, fibroblasts Differentiation of monocytes and macrophages
G-CSF Fibroblasts, monocytes, macrophages Stimulates neutrophil production in bone marrow

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