Sunday, 24 November 2013

Gastric polyps syndromes

1.JUVENILE POLYPOSIS STNDROME: > 6 polyps in rectum and colon, polyps al along GIT, family h/o polyposis syndrome.

2.FAMILIAL ADENOMATOS POLYPOSIS SYNDROME: 30 to 100 polyps, congenital hypertrophy of retinal pigment epithelium, smal intestinal adenomas, abdominal desmoid tumors, mandibular osteomas, other ca like PAP CA of thyroid, hepatoblastoma.gene is APC, 5q21 chromasome involved.

3.CRONKHITE CANADA SYNDROME: GI polyps, nail dystrophy, hyperpigmentation, alopecia.

4.GARDNER SYNDROME: GI polyps, multiple osteomas, epidermoid cyst, fibromatosis.

5.TURCOTT SYNDROME : Gi polyps,  brain meduloblastomas, brain glioblastomas.

6.LYNCH SYNDROME: GI POLYPS,  other associated ca most comonly endometrium, ovary, liver,etc.

7.MUIR TORRE SYNDROME : Gi polyps, multiple sabaecious tumors ( sebaceou ca) keratocanthomas (sq.cell ca), basal cel ca. 

8.COWEDANS DISEASE:gi polyps, facial trichillemmomas , acral keratosis,lhermitt duchlos disease. Gene involved is PTEN Gene of chromosome 10.

RAVALCADA MUIR SMITH SYNDROME : GI polyps, macrosomia, unusual facial deformities, mental retardation, pigmented macules on penis.

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